Ocular toxicity and antenatal exposure to chloroquine or hydroxychloroquine for rheumatic diseases
Identifieur interne : 002265 ( Main/Exploration ); précédent : 002264; suivant : 002266Ocular toxicity and antenatal exposure to chloroquine or hydroxychloroquine for rheumatic diseases
Auteurs : Gil Klinger [Canada] ; Yair Morad [Canada] ; Carol A. Westall [Canada] ; Carl Laskin [Canada] ; Karen A. Spitzer [Canada] ; Gideon Koren [Canada] ; Shinya Ito [Canada] ; Raymond J. Buncic [Canada]Source :
- The Lancet [ 0140-6736 ] ; 2001.
English descriptors
- Teeft :
- Abnormality, Acuity, Canadian institute, Chloroquine, Colour, Cystic, Cystic fibrosis, First trimester exposure, Frcs, Health research, Heart lung transplant, Hydrochloroquine, Hydroxychloroquine, Koren, Lancet, Lancet publishing group, Liver disease, Liver transplantation, Motherisk programme, Ocular toxicity, Ophthalmological, Ophthalmological abnormalities, Ophthalmological examination, Pigmentary retinopathy, Pregnancy outcome, Programme, Rheumatoid arthritis, Risk factors, Sick children, Systemic lupus erythematosus, Toxicity, Transplant, Transplantation, Visual abnormalities, Visual acuity, Visual fields.
Abstract
Summary: Chronic use of chloroquine and hydroxychloroquine in the treatment of rheumatic disease carries a small risk of sight-threatening pigmentary retinopathy. To obtain safety data for its use in pregnancy, we did ophthalmic examinations in 21 children born to women who took these drugs during pregnancy. Average daily maternal doses of the two drugs were 317 mg hydroxychloroquine and 332 mg chloroquine. The mean duration of gestational exposure was 72 months. No ophthalmic abnormality was detected in these children. Therapeutic use of these drugs during pregnancy may not pose a significant risk of ocular toxicity to offspring.
Url:
DOI: 10.1016/S0140-6736(01)06004-4
Affiliations:
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To obtain safety data for its use in pregnancy, we did ophthalmic examinations in 21 children born to women who took these drugs during pregnancy. Average daily maternal doses of the two drugs were 317 mg hydroxychloroquine and 332 mg chloroquine. The mean duration of gestational exposure was 72 months. No ophthalmic abnormality was detected in these children. Therapeutic use of these drugs during pregnancy may not pose a significant risk of ocular toxicity to offspring.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="Canada"><region name="Ontario"><name sortKey="Klinger, Gil" sort="Klinger, Gil" uniqKey="Klinger G" first="Gil" last="Klinger">Gil Klinger</name></region><name sortKey="Buncic, Raymond J" sort="Buncic, Raymond J" uniqKey="Buncic R" first="Raymond J" last="Buncic">Raymond J. Buncic</name><name sortKey="Ito, Shinya" sort="Ito, Shinya" uniqKey="Ito S" first="Shinya" last="Ito">Shinya Ito</name><name sortKey="Ito, Shinya" sort="Ito, Shinya" uniqKey="Ito S" first="Shinya" last="Ito">Shinya Ito</name><name sortKey="Koren, Gideon" sort="Koren, Gideon" uniqKey="Koren G" first="Gideon" last="Koren">Gideon Koren</name><name sortKey="Laskin, Carl" sort="Laskin, Carl" uniqKey="Laskin C" first="Carl" last="Laskin">Carl Laskin</name><name sortKey="Morad, Yair" sort="Morad, Yair" uniqKey="Morad Y" first="Yair" last="Morad">Yair Morad</name><name sortKey="Spitzer, Karen A" sort="Spitzer, Karen A" uniqKey="Spitzer K" first="Karen A" last="Spitzer">Karen A. Spitzer</name><name sortKey="Westall, Carol A" sort="Westall, Carol A" uniqKey="Westall C" first="Carol A" last="Westall">Carol A. Westall</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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